Particle Micronization of Medicinal Plants Extract using Electrospraying
Keywords:
electrospraying, polyvinylpyrrolidone (PVP), chitosan, starch, medicinal plantsAbstract
Phytochemical compounds are non-nutritive plant bioactive components
that contribute to disease prevention through their antioxidant and antiinflammatory
activities. In this study, particles of polyvinylpyrrolidone (PVP),
chitosan, and starch-containing phytochemical compounds from medicinal
plant extracts were prepared through an electrospray process. This method
is used to increase the bioavailability of phytochemical compounds as well
as to facilitate the storage process and durability. The effect of process
parameters in this study was investigated, the type of polymers (medicinal
plant extract/PVP, chitosan, and starch) and the electric voltage used.
Particle characterization and phytochemical properties were evaluated using
FTIR, total phenolic content (TPC), total flavonoid content (TFC), and
antioxidant activity analyses. The results showed that PVP exhibited the best
performance in binding phytochemical compounds from medicinal plants.
This was exemplified by the O. aristatus/PVP at an applied voltage of 16 kV,
which resulted in the highest total phenolic and flavonoid contents of 0.5816
mg GAE/g sample and 0.7638 mg CE/g sample, respectively. Antioxidant
activity, evaluated using antioxidant efficiency (AE), also showed the highest
value for the O. aristatus/PVP at 18 kV, reaching 0.8511 min⁻¹. FTIR analysis
indicated that PVP was able to physically interact with phytochemical
compounds, as evidenced by the overlap between the polymer and extract
spectra. In contrast, chitosan and starch exhibited relatively weaker
interactions, leading to more limited encapsulation capability and
consequently lower retention of phytochemical compounds within the
particles.
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Copyright (c) 2026 Nadya Rizkita, Bisma Hendra Setiyawan, Rais Fakhrirazin, Siti Machmudah, Sugeng Winardi, Wahyudiono
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