Non-Spherical Polymeric Nanoparticles : Synthesis and Applications
DOI:
https://doi.org/10.30595/rice.v4i2.270Keywords:
polymer, nanoparticles, non-spherical, morphology, nanocarriersAbstract
Non-spherical polymeric nanoparticles have emerged as a promising functional materials due to their distinctive physicochemical properties and enhanced performance in various applications. The morphologies of nanoparticles play a critical role in determining their biological and chemical behavior, especially in targeted delivery and interaction with complex environments. Advances in synthesis techniques now allow precise control over particle morphology, enabling the production of polymeric nanoparticles in various morphologies such as rods, discs, and ellipsoids. This review highlights recent developments in the synthesis methods of non-spherical polymeric nanoparticles and explores their expanding range of applications, with a focus on their potential as nanocarriers in biomedical, agricultural, and industrial fields.
References
C. Adhikari, "Polymer nanoparticles-preparations, applications and future insights: A concise review," Polymer-Plastics Tecnol. and Mat., vol. 60, no. 18, pp. 1996-2024, 2021, https://doi.org/10.1080/25740881.2021.1939715
A. Wasilewska, M. Bielicka, U. Klekotka, B. Kalska-Szostko, "Nanoparticle applications in food–a review," Food Funct., vol. 14, no. 6, pp. 2544-2567, 2023, doi: 10.1039/d2fo02180c
D. Nunes, S. Andrade, M. J. Ramalho, J. A. Loureiro, and M. C. Pereira, "Polymeric nanoparticles-loaded hydrogels for biomedical applications: A systematic review on in vivo findings," Polymers, vol. 14, no. 5, p. 1010, 2022, https://doi.org/10.3390/polym14051010
P. Patel, N. Vyas, M. Raval, "Safety and toxicity issues of polymeric nanoparticles: A serious concern," Nanotech. in Medicine: Toxicity and Safety, pp. 156-173, 2021.
P. Lagarrigue, F. Moncalvo, and F.Cellesi, "Non-spherical polymeric nanocarriers for therapeutics: the effect of shape on biological systems and drug delivery properties," Pharmaceutics, vol. 15, no. 1, p. 32, 2022, https://doi.org/10.3390/pharmaceutics15010032
P. Lagarrigue, F. Moncalvo, and F. Cellesi, "Non-spherical Polymeric Nanocarriers for Therapeutics: The Effect of Shape on Biological Systems and Drug Delivery Properties," Pharmaceutics, vol. 15, no. 1, p. 32, 2023, https://doi.org/ 10.3390/pharmaceutics15010032
W. Zhang et al., "Effects of morphology and size of nanoscale drug carriers on cellular uptake and internalization process: a review," RSDC Adv., vol. 13, no. 1, pp. 80-114, 2023.
S. Sahoo et al., "Preparation of polymeric nanomaterials using emulsion polymerization," Adv. in Mat. Sci. and Eng., vol. 2021, no. 1, p. 1539230, 2021.
T. Pulingam, P. Foroozandeh, J.-A. Chuah, and K. Sudesh, "Exploring Various Techniques for the Chemical and Biological Synthesis of Polymeric Nanoparticles," Nanomaterials, vol. 12, no. 3, p. 576, 2022. https://doi.org/10.3390/nano12030576
J. Zhang et al., "Polymeric non-spherical coarse microparticles fabricated by double emulsion-solvent evaporation for simvastatin delivery," Colloids and Surfaces B: Biointerfaces, vol. 199, p. 111560, 2021.
C. J. Marsden et al., "Crosslinked p (MMA) particles by RAFT emulsion polymerisation: tuning size and stability," Polymer Chem., vol. 13, no. 28, pp. 4124-4135, 2022.
A. M. Doerr, J. M. Burroughs, S. R. Gitter, X. Yang, A. J. Boydston, and B. K. Long, "Advances in polymerizations modulated by external stimuli," ACS Catalysis, vol. 10, no. 24, pp. 14457-14515, 2020.
M. Pérez-Page et al., "Template-based syntheses for shape controlled nanostructures," Adv. in Colloid and Interface Sci.,vol. 234, pp. 51-79, 2016.
R. J. C. Arshady, "Suspension, emulsion, and dispersion polymerization: A methodological survey," Colloid and Polymer Sci., vol. 270, pp. 717-732, 1992.
Y. Kitayama, S. Takigawa, and A. Harada, "Effect of Poly(Vinyl Alcohol) Concentration and Chain Length on Polymer Nanogel Formation in Aqueous Dispersion Polymerization," Molecules, vol. 28, no. 8, p. 3493, 2023, https://doi.org/ 10.3390/molecules28083493
A. Patil, S. Dyawanapelly, P. Dandekar, and R. Jain, "Fabrication and characterization of non-spherical polymeric particles," J. of Phar. Innovation, vol. 16, pp. 747-758, 2021.
N. Sudjaipraparat, C. Kaewsaneha, S. Nuasaen, and P. Tangboriboonrat, "One-pot synthesis of non-spherical hollow latex polymeric particles via seeded emulsion polymerization," Polymer, vol. 121, pp. 165-172, 2017. https://doi.org/10.1016/j.polymer.2017.06.024
F. J. Schork, Y. Luo, W. Smulders, J. P. Russum, A. Butté, and K. Fontenot, "Miniemulsion polymerization," Polymer Particles, pp. 129-255, 2005.
M. Y. Koroleva and E. V. Yurtov, "Ostwald ripening in macro-and nanoemulsions," Russian Chem. Reviews, vol. 90, no. 3, p. 293, 2021, DOI 10.1070/RCR4962.
L. Koch, S. Botsch, C. Stubenrauch, "Emulsion templating: Unexpected morphology of monodisperse macroporous polymers," J. of Colloid and Interface Sci. vol. 582, pp. 834-841, 2021, https://doi.org/10.1016 /j.jcis. 2020. 08.106
F. M. Pavel, "Microemulsion polymerization," J. of Dispersion Sci. and Tech., vol. 25, no. 1, pp. 1-16, 2004, https://doi.org/10.1081/DIS-120027662
Z. Ait-Touchente et al., "Exploring the Versatility of Microemulsions in Cutaneous Drug Delivery: Opportunities and Challenges," Nanomaterials, vol. 13, no. 10, p. 1688, 2023.
S. A. Chaudhary, D. M. Patel, J. K. Patel, and D. H. Patel, "Solvent emulsification evaporation and solvent emulsification diffusion techniques for nanoparticles," in Emerging technologies for nanoparticle manufacturing: Springer Cham., 2021, pp. 287-300.
N. R. Visaveliya and J. M. Köhler, "Emerging structural and interfacial features of particulate polymers at the nanoscale," Langmuir, vol. 36, no. 44, pp. 13125-13143, 2020.
S. Guha, and A. B. Jindal, "An insight into obtaining of non-spherical particles by mechanical stretching of micro-and nanospheres," J. of Drug Delivery Sci and Technol. vol. 59, p. 101860, 2020, https://doi.org/10.1016/j.jddst.2020.101860
J. P. Rao and K. E. Geckeler, "Polymer nanoparticles: Preparation techniques and size-control parameters," Progress in Polymer Sci., vol. 36, no. 7, pp. 887-913, 2011, https://doi.org/10.1016/j.progpolymsci.2011.01.001
X. Yan, M. Li, X. Xu, X. Liu, and F. Liu, "Zein-based nano-delivery systems for encapsulation and protection of hydrophobic bioactives: A review," Frontiers, vol. Volume 9 - 2022, 2022-September-28 2022.
B. Nagavarma, H. K. Yadav, A. Ayaz, L. Vasudha, and H. Shivakumar, "Different techniques for preparation of polymeric nanoparticles-a review," Asian J. of Pharm. and Clin. Res., vol. 5, no. 3, pp. 16-23, 2012.
S. R. Jitta and L. Kumar, "Salting out and ionic gelation manufacturing techniques for nanoparticles," in Emerging Technologies for Nanoparticle Manufacturing: Springer, 2021, pp. 129-165.
T. Pulingam, P. Foroozandeh, J.-A. Chuah, and K. J. N. Sudesh, "Exploring various techniques for the chemical and biological synthesis of polymeric nanoparticles," Nanomaterials,vol. 12, no. 3, p. 576, 2022.
K. Byrappa, S. Ohara, and T. Adschiri, "Nanoparticles synthesis using supercritical fluid technology–towards biomedical applications," Advanced Drug Delivery Reviews, vol. 60, no. 3, pp. 299-327, 2008. https://doi.org/10.1016/j.addr.2007.09.001
P. Franco and I. De Marco, "Nanoparticles and Nanocrystals by Supercritical CO2-Assisted Techniques for Pharmaceutical Applications: A Review," Applied Sci., vol. 11, no. 4, p. 1476, 2021, https://doi.org/10.3390/app11041476
T. Adschiri and A. J. T. Yoko, "Supercritical fluids for nanotechnology," The J. of Supercritical Fluids, vol. 134, pp. 167-175, 2018, https://doi.org/10.1016/j.supflu.2017.12.033
B. Esmaeili, J. Chaouki, and C. Dubois, "Nanoparticle encapsulation by a polymer via in situ polymerization in supercritical conditions," Polymer Eng. and Sci., vol. 52, no. 3, pp. 637-642, 2012.
J. P. Patterson, M. P. Robin, C. Chassenieux, O. Colombani, and R. K. O'Reilly, "The analysis of solution self-assembled polymeric nanomaterials," Chem. Society Reviews, vol. 43, no. 8, pp. 2412-2425, 2014.
A. K. Boal, F. Ilhan, J. E. DeRouchey, T. Thurn-Albrecht, T. P. Russell, and V. M. Rotello, "Self-assembly of nanoparticles into structured spherical and network aggregates," Nature, vol. 404, no. 6779, pp. 746-748, 2000.
J. P. Quiñones, H. Peniche, and C. Peniche, "Chitosan Based Self-Assembled Nanoparticles in Drug Delivery," Polymers, vol. 10, no. 3, p. 235, 2018, DOI: 10.3390/polym10030235
W. J. Zhang, C. Y. Hong, and C. Y. Pan, "Polymerization‐induced self‐assembly of functionalized block copolymer nanoparticles and their application in drug delivery," Macromolecular and Rapid Comm., vol. 40, no. 2, p. 1800279, 2019.
S. M. Hegde et al., "Nanomaterials in Food System Application: Biochemical, Preservation, and Food Safety Perspectives," in Application of Nanotechnology in Food Science, Processing and Packaging: Springer, 2022, pp. 17-30.
P. Chauhan, E. S. Chauhan, and P. Singh, "A Review of Nanotechnology Applications in Food Processing, Packaging, and Preservation," Adv. in Res., vol. 25, no. 6, pp. 427-441, 2024.
S. Sharma, L. Mulrey, M. Byrne, A. K. Jaiswal, and S. Jaiswal, "Encapsulation of essential oils in nanocarriers for active food packaging," Food, vol. 11, no. 15, p. 2337, 2022, https://doi.org/10.3390/foods11152337
E. A. Simone, T. D. Dziubla, and V. R. Muzykantov, "Polymeric carriers: role of geometry in drug delivery," Expert Opin Drug Deliv., vol. 5, no. 12, pp. 1283-1300, 2008.
M. Xu et al., "Preparation and optimization of poly (lactic-co-glycolic acid) rod-shaped particles in nano size range for paclitaxel delivery," Front Bioeng. Biotechnol., vol. 10, p. 1103990, 2022.
S. H. Ahmad Shariff, W. K. Wan Abdul Khodir, S. Abd Hamid, M. S. Haris, and M. W. Ismail, "Poly(caprolactone)-b-poly(ethylene glycol)-Based Polymeric Micelles as Drug Carriers for Efficient Breast Cancer Therapy: A Systematic Review," Polymers, vol. 14, no. 22, p. 4847, 2022, https://doi.org/10.3390/polym14224847
N. Kapate, J. R. Clegg, and S. Mitragotri, "Non-spherical micro-and nanoparticles for drug delivery: Progress over 15 years," Adv. Drug Delivery Reviews, vol. 177, p. 113807, 2021.
P. Li et al., "Evolution and recent progress of non-spherical chiral micro-and nanoparticles: preparation, design, and advanced applications," Polymer Chem., 2024.
S. J. Parkinson et al., "Polymer nanoparticles pass the plant interface," Nature, vol. 13, no. 1, p. 7385, 2022.
M. Pascoli, P. J. Lopes-Oliveira, L. F. Fraceto, A. B. Seabra, H. C. Oliveira, , "State of the art of polymeric nanoparticles as carrier systems with agricultural applications: a minireview," Energy, Ecology and environment, vol. 3, pp. 137-148, 2018.
A. Sikder, A. K. Pearce, S. J. Parkinson, R. Napier, and R. K.. O’Reilly, "Recent trends in advanced polymer materials in agriculture related applications," ACS Appl. Polymer Mat., vol. 3, no. 3, pp. 1203-1217, 2021.
S. Shakiba, C. E. Astete, S. Paudel, C. M. Sabliov, D. F. Rodrigues, and S. M. Louie, "Emerging investigator series: polymeric nanocarriers for agricultural applications: synthesis, characterization, and environmental and biological interactions," Environmental Sci.: Nano, vol. 7, no. 1, pp. 37-67, 2020.
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